Fructose 1,6-bisphosphate

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Fructose 1,6-bisphosphate
Identifiers
CAS number	[488-69-7]
PubChem	172313
MeSH	fructose-1,6-diphosphate
SMILES	C(C1C(C(C(O1)(COP(=O)(O)O)O)O)O)OP(=O)(O)O
Properties
Molecular formula	C6H14O12P2
Molar mass	340.116
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references

Fructose 1,6-phosphate is fructose sugar phosphorylated on carbons 1 and 6 (ie. is a fructosephosphate). The β-D-form of this compound is very common in cells. The vast majority of glucose and fructose entering a cell will become converted to fructose 1,6-phosphate at some point.

[edit] Fructose 1,6-phosphate in glycolysis

Fructose 1,6-phosphate lies within the glycolysis metabolic pathway and is produced by phosphorylation of fructose 6-phosphate. It is in turn broken down into two compounds; glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. It is an allosteric activator of pyruvate kinase.

β-D-fructose 6-phosphate	6-phosphofructo 1-kinase		β-D-fructose 1,6-phosphate	Fructose bisphosphate aldolase		D-glyceraldehyde 3-phosphate		dihydroxyacetone phosphate
							+
	ATP	ADP
	Pi	H2O
	Hexose diphosphatase			Fructose bisphosphate aldolase

Compound C05345 at KEGG Pathway Database. Enzyme 2.7.1.11 at KEGG Pathway Database. Enzyme 3.1.3.11 at KEGG Pathway Database. Compound C05378 at KEGG Pathway Database. Enzyme 4.1.2.13 at KEGG Pathway Database. Compound C00111 at KEGG Pathway Database. Compound C00118 at KEGG Pathway Database.

The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.

[edit] Fructose 1,6-phosphate isomerism

Fructose 1,6-phosphate has only one biologically active isomer, the β-D-form. There are many other isomers, analogous to those of fructose.

[edit] See also

• Fructose 2,6-bisphosphate

v • d • e Glycolysis Metabolic Pathway

Glucose Hexokinase Glucose 6-phosphate Glucose-6-phosphate isomerase Fructose 6-phosphate phosphofructokinase-1 Fructose 1,6-bisphosphate Fructose bisphosphate aldolase ATP ADP ATP ADP Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Triosephosphate isomerase Glyceraldehyde 3-phosphate Glyceraldehyde-3-phosphate dehydrogenase 1,3-Bisphosphoglycerate NAD+ + Pi NADH + H+ + 2 2 Phosphoglycerate kinase 3-Phosphoglycerate Phosphoglycerate mutase 2-Phosphoglycerate Phosphopyruvate hydratase(Enolase) Phosphoenolpyruvate Pyruvate kinase Pyruvate ADP ATP H2O ADP ATP 2 2 2 2 see also disorders